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By Jackie D. And Roger A. Johnson Corbin

Novel ways for the examine of phosphodiesterases and phosphoprotein phosphatases, in addition to these of nonmammalian cyclic nucleotide receptors, are emphasised for the 1st time within the Methods of Enzymology sequence. New tools for the examine of protein kinases also are offered

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Garcia and S. G. Rhee, J. Biol. Chem. 258, 2246 (1983). 43 C. E. C a b a n and A. Ginsburg, Biochemistry 15, 1569 (1976). 44 D. C. La Porte and D. E. , Nature (London) 300, 458 (1982). 45 M. R. E1-Maghrabi, T. H. Claus, J. Pilkis, E. Fox, and S. J. Pilkis, J. Biol. Chem. 257, 76O3 (1982). 46 E. Van Schaftingen, D. R. Davies, and H. G. Hers, Eur. J. Bioehem. 142, 143 (1982). [1] c A M P IN CYCLIC CASCADE REGULATION 13 Apparent cooperativity can also be obtained through tight complex formation between the active converter enzyme and the interconvertible enzyme such that the converter enzyme is saturated by its protein subs t r a t e .

185-202. Academic Press, New York, 1979. 4~ E. R. Stadtman and P. B. Chock, in "The Neurosciences Fourth Study Program" (F. O. ), pp. 801-817. MIT Press, Cambridge, Massachusetts, 1979. [1] cAMP IN CYCLICCASCADEREGULATION 11 variety of responses to increasing concentrations of primary allosteric stimuli. (6) They can serve as rate amplifiers to hasten the response to changes in metabolite levels. The following sections describe these important properties in greater detail. Signal Amplification.

M. G. , R. H. Haschke, and E. H. Fischer, J. Biol. Chem. 245, 6642 (1970). 53 W. H. Danforth, E. Helmreich, and C. F. Cori, Proc. Natl. Acad. Sci. A. 48, 1191 (1962). a ATP c-AMP i ~,,.. A M P ~ R2C2 R2 ' (c-AMP)4 2C. . . ATP~L~ o-I A DP m-I . . . pi ~ - - - ' ~ H 2 0 s Flo. 1. Schematic of the cAMP cascade. AC, adenylate cyclase; R2C2, cAMP-dependent protein kinase; 0-I, unmodified form of an interconvertible protein; m-l, modified form of an interconvertible protein; S and P, substrate and product of the activated interconvertible enzyme.

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